Born to Run?

Born to run. Studying the limits of human performance

It is recognised that regular physical activity and a high level of fitness are powerful predictors of positive health outcomes. There is a long and rich history of significant feats of human endurance with some, for example, the death of the first marathon runner, Pheidippides, associated with negative health outcomes. Early studies on endurance running used X-ray and interview techniques to e...

Born to run; the story of the PEPCK-Cmus mouse.

In order to study the role of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) (PEPCK-C) in skeletal muscle, PEPCK-Cmus mice were created by introducing the cDNA for the enzyme, linked to the human alpha-skeletal actin gene promoter, into their germ line. Two founder lines generated by this procedure were bred together, creating a line of mice that have 9.0 units/g sk...

Cytoskeleton: Microtubules Born on the Run

The organization of microtubules into large arrays determines cell morphology and structure. Recent work in the fission yeast describes a novel mechanism for microtubule self-organization in the absence of centrosomes; this mechanism may function in a variety of cell types found in diverse organisms.

Macroscopic observables and the Born rule I. Long run frequencies

We clarify the role of the Born rule in the Copenhagen Interpretation of quantum mechanics by deriving it from Bohr’s doctrine of classical concepts, translated into the following mathematical statement: a quantum system described by a noncommutative C-algebra of observables is empirically accessible only through associated commutative C-algebras. The Born probabilities emerge as the relative f...

Run-to-Run Control in Semiconductor Manufacturing